Article: Prevalence of Vitamin D Deficiency in Chronic Liver Disease by, Arteh J, Narra S, Nair S. Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Source: Dig Dis Sci. 2010 Sep;55(9):2624-8. Epub 2009 Dec 4.
Summary by Alan Franciscus
There has been a lot of news about vitamin D deficiency in the general population and in liver disease. There has been some evidence that suggest that cirrhosis interferes with the metabolism of calcium and vitamin D. In the current small study the authors sought to determine the prevalence of vitamin D deficiency.
One hundred and eighteen people—43 people with hepatitis C cirrhosis, 57 people with hepatitis C but who did not have cirrhosis, and 18 people with non-hepatitis C-related cirrhosis—were seen consecutively while attending the University of Tennessee Hepatology Clinic. The study participants had their vitamin D level measured.
The severity of vitamin D deficiency was graded as mild—20-32 ng/ml, moderate—7-19 ng/ml, or severe—32 ng/ml.
Almost all of the patients were found to have some degree of vitamin D deficiency—109 out of 118 patients (92.4%). In the group with cirrhosis 16.3% had mild, 48.8% had moderate, and 30.2% had severe vitamin D deficiency. In the group with no cirrhosis, 22.8% had mild, 52.6% had moderate, and 14% had severe vitamin D deficiency. In the group of those with cirrhosis (but not hepatitis C) 38.9% had mild, 27.8% had moderate, and 27.8% had severe vitamin D deficiency. Patients with cirrhosis were more likely to have severe vitamin D deficiency (Share This Page