Interview conducted by April Cashin-Garbutt, BA Hons (Cantab)
Please can you give a brief introduction to genotype-1b hepatitis C and how it differs from subtype 1a?
Genotype 1 is, worldwide, the most prevalent genotype of the hepatitis C virus. It accounts for around seventy percent of all hepatitis C infections.
With the introduction of protease inhibitors, it became known that the
subtypes 1a and 1b make a difference in terms of treatment response.
Subtypes 1a and 1b are genetically closely related. They share seventy
to eighty percent of their genome. However, 1a turned out to be more
difficult to treat than 1b, which is easier to treat.