—Lucinda K. Porter, RN
Virus Maintains Infectivity for Weeks after Drying on Inanimate
Surfaces at Room Temperature: Implications for Risks of Transmission –
Elijah Paintsil, et al.
Source: Journal of Infectious Diseases published online November 23, 2013
C virus remains potentially infectious, and to evaluate the
effectiveness of antiseptics. Researchers tested hepatitis C under a
variety of conditions, trying to mimic average circumstances that
people may come in to contact with hepatitis C on surfaces.
virus remains potentially infectious on surfaces for up to six weeks.
Infectivity increased with high viral load, temperature, and humidity.
Commercial antiseptics, such as bleach and alcohol reduce hepatitis C
infectivity, but only if used as directed at full strength.
is disturbing, but may explain some of the hepatitis C infections in
people with no known risk factors. The authors discuss patients whose
only risk factors were hospital admissions (no procedures), opening the
door for a broader explanation for how people may acquire hepatitis C.
Interferon Free Regimens on Clinical and Cost Outcomes for Chronic
Hepatitis C Genotype 1 Patients – Zobair M. Younossi, et al. (Blogged
Dec 2, 2013)
Source: Journal of Hepatology in press November 20, 2013
evaluated the cost effectiveness of treating patients with genotype-1
hepatitis C with an oral interferon-free (IFN-free) regimen versus
triple therapy using IFN, ribavirin, and a hepatitis C protease
treatments were not available for this analysis. Here is how the
researcher approached this: “The baseline cost of oral therapy was
calibrated such that the average total treatment cost of oral therapy
was equal to the average total treatment cost of triple therapy,
despite the shorter duration of oral therapy. This resulted in a
baseline cost of oral therapy of $5,800 per week. We also considered
the scenario where this baseline cost was increased by 50% to $8,700
is $84,000 for 12 weeks. Add in the cost of ribavirin, medical
appointments, labs, and so on, and my guess is that triple therapy will
come out ahead IF you only consider price.
of drugs that patients can and will use. If we made decisions solely
based on the cost of treatment, then many people I know would prefer to
take their chances with hepatitis C. The real bottom line is
effective, tolerable, and affordable treatment for all hepatitis C patients.
Not Fruit Fructose Intake Is Associated with the Severity of Liver
Fibrosis in Genotype 1 Chronic Hepatitis C Patients – Salvatore Petta,
Source: Journal of Hepatology December 2013; Volume 59, Issue 6, Pages 1169-1176
manufactured, such as high-fructose corn syrup (HFCS). This study
evaluated the impact of fruit versus industrial fructose in the diets
of 147 genotype 1 hepatitis C patients.
liver fibrosis was limited to industrial fructose in the diet, and not
to fruit fructose. Industrial fructose is associated with obesity and
other metabolic diseases.
nutritionists are concerned about sugar in the diet, particularly for
those with liver disease. Industrial fructose has no known health
benefits, and the list of reasons why it should be avoided is growing.
If giving up or reducing sugar intake is a struggle for you, or
something you don’t want to do, then at least consider abstaining from
high-fructose corn syrup.
Virus Infection and Risk of Stroke: A Systematic Review and
Meta-Analysis – He Huang, et al. (Blogged December 2, 2013)
Source: PLOS ONE November 2013; Volume 8, Issue 11
worldwide,” write the authors of this paper. Hepatitis C has been
associated with increased risk of stroke, and these researchers
performed a thorough meta-analysis of the data to gain further insight.
infection was associated with a significant increased risk of stroke.
The physiological reasons for this risk are unknown. Some theories for
why hepatitis C may increase stroke risk are increased plague in the
carotid arteries, chronic inflammation, and hepatitis C-related
metabolic disorders, such as diabetes.
Editorial Comment: Although this
analysis isn’t hard proof that hepatitis C can raise stroke risk, it
adds validity to other research showing a disturbing trend that chronic
hepatitis C infection is a serious disease that affects both quality
and quantity of life.