CONCORD, New Hampshire —
The New Hampshire House has passed a drug testing bill inspired by the
hepatitis C outbreak at Exeter Hospital.
The bill, which now goes to the Senate, would require
hospitals to test employees for drugs if there was a reasonable
suspicion of drug use. It was inspired by the case of David Kwiatkowski
(kwiht-KOW’-skee), who was sentenced in December to 39 years in prison
after admitting he stole painkillers from the hospital and replaced them
with saline-filled syringes tainted with his blood.
Seattle Children’s hospital this week notified about 100 patients
they may be at risk for infection from colonoscopy equipment that had
not been properly cleaned.
The cleaning-process lapse was discovered in early November and
involved two auxiliary channel scopes, Children’s said in today’s
statement. The scopes, which differ from the standard scopes, have a
special channel that requires extra attention. The hospital found that
technicians weren’t sufficiently trained on cleaning procedures, which
led to the scopes being used again before they were ready, according to
In the race for new hepatitis C therapies, Bristol-Myers Squibb is done courting Gilead , maker of the first all-oral treatment for hepatitis C Sovaldi (sofosbuvir.)
Following Gilead’s approval of Sovaldi, Bristol-Myers has long been
trying to convince Gilead to join forces in a combination drug of
sofosbuvir and Bristol-Myers’ daclatasvir. However, Gilead has resisted a
partnership and has maintained its potential combination drugs
With daclatasvir’s approval pending in Europe, Bristol-Myers has
garnered the confidence to break away from a possible partnership and
piggyback its use with Gilead’s sofosbuvir potentially off-label.
Medically, the combination of daclatasvir and sofosbuvir has shown
stellar results. Studies have shown that 12-week combination therapy
cleared 100% of the virus in a study of 41 patients who were refractory
to prior treatments of Incivek and Victrelis, gold standard treatments
for hepatitis C .
Gilead’s in-house sofosbuvir-ledipasvir combination has proven
that it offers potentially better results for genotype 1, the major
genotype of HCV. However, Bristol-Myers’ proposed daclatasvir and
sofosbuvir combination looks like it is preferential for the less
prevalent, but still significant, population of patients with genotype
3. What it lacks in reach of patient population, Bristol-Myers has made
up with in time – likely the European approval of daclatasvir will come
before approval of Gilead’s in-house combination.
On January 17, 2014, FDA approved changes to the Victrelis (boceprevir)
package insert to expand the list of contraindicated medications and
update the Drug Interaction section.
Doxazosin, silodosin and tamsulosin, alpha 1-adrenoreceptor antagonists, were added to the section 4 Contraindications due to the potential for alpha 1-adrenoreceptor antagonist-associated adverse events such as hypotension and priapism.
In section 7 Drug Interactions the calcium channel blockers, amlodipine, dilitiazem, nisoldipine and verapamil were added.
The complete, revised label will be posted soon to the Drugs@FDA, and DailyMed sites.
Victrelis is a product of Merck & Co.
Richard Klein Office of Health and Constituent Affairs Food and Drug Administration
Kimberly Struble Division of Antiviral Drug Products Food and Drug Administration
BRANTFORD, Ont. – Human error may have led to cross-contamination of
medication supplies in the cases of two patients who recently acquired
hepatitis C after undergoing endoscopies at Brantford General Hospital.
Tom Szakacs, an infection control specialist at BGH, said Tuesday that
medications used in sedation during endoscopies must be carefully
documented, including the type of drug and dose. He said that in some
cases “some pieces of information were not there.”
France has stopped free treatment of Georgian citizens suffering from
hepatitis C, human rights activist Dmitry Lortkipanidze and executive
director of the Georgian- French friendship association Nugzar
Sulashvili said at a briefing on Tuesday.
“France made this decision on August 6, 2013, after the French
embassy learned a hepatitis C free treatment program was used in
Georgia,” Sulashvili added. “However, it was not indicated that the
program is valid only in the penal system.”
Around 400-5,000 Georgian citizens suffering from hepatitis C are
being treated in France. They are subject to deportation, he said.
Melodic rock singer Dennis Hardy “Fergie” Frederiksen passed away yesterday (January 18) after a lengthy battle with liver cancer. He was 62 years old.
Frederiksen was best known as the former vocalist of TOTO (on the “Isolation” album, released in 1984), as well as his involvement involved in a lot of other outstanding musical projects: TRILLION, LEROUX, FREDERIKSEN/PHILIPS, MECCA, FREDERIKSEN/DENANDER and DAVID LONDON (solo album, under pseudonym). In 1999 he debuted as a solo artist with “Equilibrium”, an album which garnered great reviews in Europe and Japan and since then he has been offering quality melodic rock music to his legion of fans.
Read more at http://www.blabbermouth.net/news/former-toto-singer-fergie-frederiksen-dead-at-62/#U16ZFPBVecwd8jBo.99