A triple-punch of antibodies both prevented hepatitis C infection and
wiped out the disease after it had established itself in laboratory
mice, according to a study led by Princeton University researchers.
Instead of delivering the three antibodies directly, the researchers
administered a genetic “instruction set” that, once in a cell, developed
into antibodies that target the portions of the virus that do not
Mice treated with the antibody genetic code resisted becoming infected with hepatitis C when they were exposed to the virus, the researchers reported
in the Sept. 17 issue of the journal Science Translational Medicine.
The researchers also gave the antibodies to mice that already were
infected and found that, in many cases, the infection disappeared to
levels below detection.