—Alan Franciscus, Editor-in-Chief
It should not surprise anyone with hepatitis C (HCV) that having
hepatitis C can lead to depressive symptoms and a reduction in quality
of life. Would it be a surprise that being cured of hepatitis C
would reduce the symptoms of depression and improve quality of life?
Probably not! I will be very interested to read the entire research
paper about this study to learn more.
Lucinda Porter, RN will report on another study
that looked at people who had minimal disease who had to wait for
treatment and what effect it had on their emotional state. The recap
of the study will appear in the next issue of the HCV Advocate newsletter. Alan
Predictors of poor mental and physical
health status among patients with chronic hepatitis C infection: The
chronic hepatitis cohort study (CHeCS).
Boscarino et al.
Hepatology. 2014 Sep 9. doi: 10.1002/hep.27422. [Epub ahead of print]
Our objective was to assess the extent and risk
factors for depression and poor physical health among patients with
chronic hepatitis C virus (HCV) infection.
We surveyed HCV-infected patients seen at four
large healthcare systems participating in the Chronic Hepatitis Cohort
Survey data included demographics, depression and
physical health measures, substance use history, current social
support, recent stressor exposures, and, from the electronic medical
record, treatment history, and Charlson Comorbidity Index scores.
There were 4,781 respondents, who were a mean of 57
years old, 71% White, and 57% male. Altogether, 51.4% reported past
injection drug use, 33.9% were current smokers, and 17.7% had abused
alcohol in the previous year. Additionally, 47.4% had been previously
treated for HCV and 14.8% had a 12-week sustained viral response (SVR)
following HCV therapy. Overall, 29.7% of patients met criteria for
current depression and 24.6% were in poor physical health.
In multivariate analyses, significant predictors of depression and poor health included:
- Male gender (vs. female, OR, 0.70 and 0.81),
- Black race (vs. white, ORs, 0.60 and 0.61),
- Having education less than high school (vs. college, ORs, 1.81 and 1.54),
- Being employed (vs. not, ORs, 0.36 and 0.25),
- Having high life stressors (vs. low, ORs, 2.44 and 1.64),
- Having low social support (vs. high, ORs=2.78 and 1.40), and
- Having high Charlson scores (vs. none, ORs=1.58 and 2.12).
Achieving a 12- week SVR was found to be protective for depression.
This large survey of US HCV patients indicates the
extent of adverse health behaviors and mental and physical
comorbidities among these patients. (Hepatology 2014;).
Copyright © 2014 American Association for the Study of Liver Diseases.Share This Page