Good news for coffee lovers! A new research just found that coffee can actually help keep the liver in good health.
Findings by a team from the Monash University found that drinking 2 or more cups of coffee a day can help prevent liver diseases and even reduce damage caused by some of these conditions.
“Certainly moderate amounts of coffee, depending on the liver disease you’re looking at, seem to be associated with less liver damage and probably less liver fat, as well,” reported Dr. Alex Hodge, a liver specialist from Monash Health who was also part of the research team.
SAN FRANCISCO, Nov. 16, 2015 /PRNewswire/ — The direct acting antivirals that have been used to treat many patients with hepatitis C virus and cure almost all treated in the past two years has led to many questions for the healthcare system including the impact on the transplant wait list. Researchers at Hahnemann University Hospital Drexel College of Medicine presented data at the Annual Meeting of the American Association for the Study of Liver Diseases on the specific topic of curing patients with decompensated hepatitis C cirrhosis similar to those patients who are on the waitlist for transplantation.
Viral hepatitis is a frequent cause of decompensated cirrhosis, which starts as compensated cirrhosis in which there are no symptoms of the scarring of the liver (cirrhosis). The symptoms of progression to decompensated cirrhosis, which is life-threatening unless a liver transplant is performed, are bleeding varices, ascites, encephalopathy, and jaundice.
Patients with decompensated HCV cirrhosis comprise 30 percent of adults on the transplant list waiting for a liver. Treating these patients successfully with antiviral therapy will change their Model End-Stage Liver Disease (MELD) scores. MELD scores control patient priority on the waiting list. Patients with a MELD score of 15 or lower are less likely to benefit from transplantation.
First Data to Report on Denial and Delay Rates for Hepatitis C Antiviral Agents
SAN FRANCISCO — Nearly 50 percent of Medicaid patients infected with chronic hepatitis C whose doctors had prescribed newer, life-saving antiviral drugs were denied coverage to the therapies because they weren’t considered “a medical necessity” or because the patients tested positive for alcohol/drugs, among other reasons, according to new Penn Medicine research. The data was revealed through a prospective analysis of prescriptions submitted to a specialty pharmacy that services patients in Pennsylvania, New Jersey, Delaware and Maryland.
Vincent Lo Re III, MD, MSCE, an assistant professor of Medicine and Epidemiology in the division of Infectious Diseases at the Perelman School of Medicine at the University of Pennsylvania and the Center for Clinical Biostatistics and Epidemiology, will report the findings at the American Association for the Study of Liver Diseases (AASLD) 2015 Liver Meeting (Abstract #LB-5).
In a City of Hope study recently published in the journal PLOS One, researchers found that people successfully vaccinated against hepatitis B had a 33 percent drop in diabetes risk when compared to people who had not received the vaccine. “Successful” vaccination means people have antibodies against hepatitis B in the bloodstream – a sign that they’re protected against the disease.
One of the authors of the study, Ken C. Chiu, M.D., a professor of Clinical Diabetes, Endocrinology & Metabolism, is now at work on a new study to further investigate the potential link between the vaccine and diabetes resistance.
Doctors already knew of the association between diabetes and hepatitis B, a virus that infects the liver, and researchers have been exploring the possibility that diabetes might be triggered by bacteria, viruses or other disease-causing organisms. What’s important about this new study is that it shows just how vital this line of research may prove to be.
Daclatasvir+sofosbuvir+ribavirin regimen achieves SVR12 rates of 88% and 92% overall for 12 or 16 weeks of therapy respectively in GT-3 patients with advanced fibrosis or cirrhosis
MONTREAL, Nov. 16, 2015 /CNW/ – Bristol Myers-Squibb today announced late-breaking data from the Phase 3 ALLY-3+ Trial investigating a regimen of Daklinza™ (daclatasvir, DCV) in combination with sofosbuvir (SOF) and ribavirin (RBV) in genotype 3 hepatitis C (HCV) patients with advanced fibrosis or cirrhosis, for treatment durations of 12 and 16 weeks. This patient population is one of the most difficult to treat, among whom sustained virologic response (SVR) rates, or cure, have proved harder to achieve with existing therapies.
The results show that SVR12 rates in cirrhotic patients only were 83 per cent and 89 per cent in the 12- and 16-week arms, respectively. Results will be presented at The Liver Meeting® 2015, the Annual Meeting of The American Association for the Study of Liver Diseases (AASLD), in San Francisco, CA, November 13 – 17.
Daklinza is a potent, pan-genotypic NS5A replication complex inhibitor (in vitro) that has been approved for use in combination with sofosbuvir (marketed in Canada by Gilead Sciences Canada Inc. as SOVALDI™) as a convenient, all-oral, once-daily regimen for the treatment of adult patients with hepatitis C genotypes 1 and 2 with compensated liver disease including cirrhosis. Daklinza has also received a Notice of Compliance with conditions (NOC/c) from Health Canada for the treatment of genotype 3 patients with compensated liver disease including cirrhosis. In Canada, genotypes 3 accounts for 20 per cent of hepatitis C infections.
Merck Advances to Part B of C-CREST Phase 2 Clinical Development Program
KENILWORTH, N.J.–(BUSINESS WIRE)–Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced the presentation of results from the initial phase (Part A) of the company’s C-CREST 1 and 2 Phase 2 clinical development program evaluating two investigational all-oral, triple-combination treatment regimens – a regimen of grazoprevir1, MK-36822 and elbasvir3; and a regimen of grazoprevir, MK-3682 and MK-84084 – in treatment-naïve patients with chronic hepatitis C virus (HCV) genotypes (GT) 1, 2 or 3 infection. These data will be presented today during a late-breaking abstract session at The Liver Meeting® (Abstract #LB-15). Based on the results of this initial trial, Merck has initiated further study of grazoprevir (100mg), MK-3682 (450mg) and MK-8408 (60mg) in the second phase (Part B) of the C-CREST Phase 2 clinical development program.
“Merck’s chronic hepatitis C development program continues to focus on the goal of advancing a short-duration treatment regimen that offers high virologic cure rates across all viral genotypes,” said Dr. Roy Baynes, senior vice president and head of global clinical development, Merck Research Laboratories. “The strong results observed in this study support the further investigation of the novel triple-combination regimen of grazoprevir, MK-3682 and MK-8408 in patients with chronic hepatitis C.”
In these randomized, open-label clinical trials, C-CREST 1 evaluated treatment-naive, non-cirrhotic patients with chronic HCV GT1 or 2 infection and C-CREST 2 evaluated treatment-naive, non-cirrhotic patients with chronic HCV GT3 infection. The primary efficacy endpoint was sustained virologic response 12 weeks after the completion of treatment (SVR12, or virologic cure). All 240 enrolled patients completed eight weeks of treatment and reached follow-up 12 weeks after end of treatment. Treatment with grazoprevir (100mg), MK-3682 (450mg) and MK-8408 (60mg), without ribavirin (RBV), for eight weeks resulted in virologic cure rates of greater than 90 percent across chronic HCV patients with GT1, 2 or 3 infection, which supported the decision to advance this regimen into Part B of the C-CREST Phase 2 clinical trial program.
AbbVie (NYSE: ABBV) announced data from the SURVEYOR studies of its investigational HCV regimen, ABT-493, an NS3/4A protease inhibitor, and ABT-530, an NS5A inhibitor, that show high rates of sustained virologic response at 12 weeks post-treatment (SVR12) in non-cirrhotic patients with chronic hepatitis C virus (HCV) infection. After 12 weeks of treatment, SVR12 rates achieved were 97-100 percent in genotype 1 (GT1), 96-100 percent in genotype 2 (GT2) and 83-94 percent in genotype 3 (GT3) patients.1,2,3 These data are being presented at The Liver Meeting® 2015, the Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in San Francisco.
Separately, in a late-breaking presentation of the SURVEYOR-I study, data show non-cirrhotic GT1 chronic HCV patients who received a shorter duration of treatment for 8 weeks with ABT-493 and ABT-530 achieved a SVR12 rate of 97 percent.4
Note: This is a prime example of why we need to treat early and eliminate the progression to liver cancer. Alan
SAN FRANCISCO, Nov. 15, 2015 /PRNewswire/ — Hepatocellular carcinoma (HCC) remains one of the cancers growing in frequency and mortality in the United States. Patients with hepatitis C virus (HCV) left untreated will often progress to cirrhosis and HCC. Direct acting antivirals (DAAs) now used to treat patients with HCV have achieved almost universal cure rates. However, the risk of HCC following cure is not clear. Researchers from Houston VA Medical Center and Baylor College of Medicine (Houston, TX) presented data at the annual meeting of the American Association for the Study of Liver Diseases on the risk of developing HCC in patients with HCV who have achieved sustained virologic response (SVR).
This retrospective national cohort study examined the records of patients who achieved SVR using interferon-based therapy and who had at least one year of follow up in the national VA system. There were 10,738 patients who achieved SVR and had no HCC prior to SVR. Of those patients who achieved SVR, 100 developed HCC after SVR.
Dr. El-Serag, the study’s principal investigator, concluded that the risk of developing HCC after being cured of HCC remains elevated with an overall incidence of 0.33 percent per year. Being older, or having cirrhosis at the time of SVR were associated with annual HCC risk of 0.9% and 1.55%, respectively. Diabetes and previous genotype 3 were also associated with an additional increased risk of developing HCC after HCV cure. Dr. El-Serag addresses those at an increased risk of developing HCC, “Subgroups such as age 65 years and older, those with diabetes and especially those with cirrhosis have even higher rates — closer to or higher than 1 percent per year — of developing HCC.”