AASLD 2016: The Liver Meeting
Abstract t #1446 The Fatigue of Chronic Liver Disease is Associated with Altered Circadian Rhythm of Cortisol – Michele M. Tana, et al.
Fatigue is a common complaint for patients with liver disease, and researchers don’t completely know the cause of this. Scientists noticed that patients with chronic liver disease (CLD) had various signs and symptoms associated with circadian rhythms, also known as sleep-wake patterns. Were these problems caused by the brain’s master clock or in the liver’s clock?
This prospective study enrolled 12 subjects with CLD; six had fatigue and six did not. They took blood samples at various times while evaluating fatigue level.
Conclusion: Looking at various factors, they found that the circadian rhythms of cortisol were “significantly disrupted in CLD patients with fatigue.”The researchers recommend more studies examining the hypothalamic-pituitary-adrenal axis in the brain to help us find ways to improve fatigue in CLD patients.
Editorial Comments: This study only looked at the broader picture of liver disease. People who have hepatitis C may have additional factors that contribute to fatigue.
Lucinda K. Porter, RN, is a long-time contributor to the HCV Advocate and author of “Free from Hepatitis C” and “Hepatitis C One Step at a Time.” She blogs at www.LucindaPorterRN.com and HepMag.com
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