Note: This is a frequently asked question at our training workshops! Alan
In acute hepatitis C infection, the amount of time when a patient is virologically positive but IgG antibody (Ab) negative, referred to as the pre-seroconversion window, differs depending on the method used. Researchers from Johns Hopkins School of Medicine and the National Institute of Allergy and Infectious Diseases in Baltimore, Maryland used various assay algorithms to better understand that window period.
The researchers pulled data from studies on commercially available hepatitis C seroconversion panels. They evaluated primary viral infection and subsequent IgG Ab seroconversion and presented their findings were presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2017) in Seattle, Washington.
Laboratory results were gathered from 82 repeat donors, making up 754 visits. Thirty-nine of them were excluded—23 were hepatitis C RNA positive at baseline, 12 remained hepatitis C negative during the study period, and four whose interval to estimate the initial infection date more than 30 days.