WATERTOWN, Mass.,–(BUSINESS WIRE)–Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a chemistry-driven biotechnology company dedicated to creating and developing small molecule drugs for viral infections and liver diseases, today announced that AbbVie’s MAVIRET™ (glecaprevir/pibrentasvir), a new once-daily, ribavirin-free treatment approved for adults with chronic hepatitis C virus (HCV) infection across all major genotypes (GT1-6) in Japan, has been approved for reimbursement by the Ministry of Health, Labour and Welfare and is now commercially available in Japan. MAVIRET is the first and only 8-week treatment in Japan for genotype 1 (GT1) and genotype 2 (GT2) HCV infected patients without cirrhosis and who are new to direct-acting antiviral (DAA) treatment.*
Glecaprevir, one of the two new, direct-acting antivirals (DAAs) in MAVIRET (marketed as MAVYRET™ in the U.S.), is Enanta’s second protease inhibitor being developed and commercialized by AbbVie. With the reimbursement approval in Japan, Enanta has now earned a $15 million milestone payment, which it expects to receive this quarter.
“Enanta has now earned all of the clinical and regulatory milestones for two products, paritaprevir and now glecaprevir, within the Enanta/AbbVie HCV collaboration,” stated Jay R. Luly, Ph.D., President and CEO. “AbbVie has recently stated that it is confident that the MAVIRET combination therapy will allow AbbVie to significantly grow its position within the HCV market globally, and that it will ultimately deliver a multibillion-dollar peak-year of sales. We are fortunate to have a partner that is bringing such important therapies as MAVIRET to HCV patients in markets around the world.”