1. Both 8 and 12-week regimens of glecaprevir-pibrentasvir were highly efficacious in producing sustained virologic response in patients infected with hepatitis C virus (HCV) genotypes 1 and 3, and the 8-week treatment duration was noninferior to 12-week duration.
2. Similar low rates of serious adverse events or clinically significant laboratory abnormalities with seen with both the 8 and 12-week combination regimen.
Researchers in California and Brazil said a drug meant to treat and cure hepatitis C could be as effective in treating people infected with Zika, especially in protecting the fetus of an infected pregnant women.
Researchers associated with the University of California San Diego and colleagues in Brazil found that in cellular and mice trials, the anti-viral medication Sofosbuvir, brand name Sovaldi, was effective in repairing cells damaged by Zikaand blocking the transmission of the virus to the fetus of a pregnant mouse.
“This suggests that one, the drug was well-tolerated by the Zika-infected pregnant mice and two, more importantly, that it was able to arrest Zika replication in vivo and stop transmission from mother to fetus,” senior author Dr. Alysson Muotri, a professor in the U.C. San Diego School of Medicine departments of Pediatrics and Cellular and Molecular Medicine, said in a statement.
he San Diego County Board of Supervisors ended its hepatitis A emergency declaration Tuesday, underscoring again the cluelessness with which city and county officials first reacted to a public health disaster that left 20 dead and 577 ill from a disease that vaccinations had largely wiped out across America but that was allowed to spread among the city’s vulnerable homeless population.
That government officials’ concerted efforts quickly halted the spread of the disease shouldn’t make anyone in the community forget their initial lack of urgency. City and county officials who dragged their feet over the first steps finally treated the situation like an emergency only after a string of headlines about their bureaucratic bungling. Subsequent stories made clear that officials had ignored warning signs for far too long, failing for years to install public bathrooms for a growing homeless population or power-wash city streets. In San Diego, 10 portable restrooms and a few hand-washing stations will remain, but others are already removed. County officials will continue vaccinating the most at-risk groups, including those in jail and shelters.
Just because you can’t vote yet doesn’t mean you can’t voice your view on things that matter to you. Your representatives in congress represent everyone in their district, including children. By reaching out to your congressman or woman, you can help influence their vote on potential laws and regulations that affect you, your family, your friends or your community.
You see, congressmen and women really do care what their constituents (the people they represent) think. They even have staffers whose sole job is to tally up the opinions of everyone who contacts the congressional office. Quite frequently, these congress members will change their vote on something if as few as seven people call in their support or dissent. That means a few minutes of your time can make a huge difference.
Who do I contact?
Everyone, including kids, is represented by three members of the U.S. Congress. Remember that the U.S. Congress is made up of two branches: the House and the Senate.
One of your representatives is in the House of Representatives. There are a total of 435 districts in the United States, and each elects their own House representative. Your congressman in the House is generally addressed by the title “Representative [Last Name],” but may also be called “Congressman [Last Name].”
Your other two representatives are in the Senate, and both represent your entire state. They are addressed by the title “Senator [Last Name.”] There are two senators per state making 100 total in the U.S. Senate.
The House and Senate vote separately, and both must approve a bill in order for the President to have an opportunity to sign it into law or veto it. That means if you care about an issue, you will want to contact all three of your representatives.
SAN DIEGO – The Board of Supervisors voted Tuesday to end a state of emergency declaration over the hepatitis A outbreak in San Diego County amid a declining number of cases.
There have been no new reported cases of the illness over the last four weeks and the number of deaths linked to the disease has remained at 20 since late October. Those are two signs that the county’s three-pronged approach — vaccinating people who are at risk of contracting the disease, educating the public about prevention and sanitizing streets — has worked, health officials told the board.
“The outbreak activity has leveled off to near zero,” said Dr. Wilma Wooten, the county’s public health officer.
Sovaldi with ribavirin was safe and effective among a cohort of Japanese patients with hepatitis C genotype 2, according to a recently published study. However, renal dysfunction correlated significantly with a lower rate of sustained virologic response.
“HCV infection causes renal dysfunction via membrane-proliferative glomerulonephritis due to mixed cryoglobulinemia, and HCV eradication sometimes results in the improvement of renal dysfunction,” Takuya Sho, MD, from the Hokkaido University, Japan, and colleagues wrote. “As patients with HCV infection are getting older, age-related renal dysfunction becomes an additional problem. Thus, effective and safe treatment is highly required for HCV-infected patients with renal dysfunction.”
Important Note:The original report that I posted is a poorly written report. The link here is a direct link to the published report from The U.S. Dept. of Health and Human Services. Characteristics of Inpatient Stays Involving Hepatitis C, 2005-2014.
The important take home of the study is:
-Baby boomers (patients aged 52-72 years) had the highest rate of inpatient stays involving hepatitis C in 2014: 503.1 per 100,000 population versus 155.4 for younger patients and 117.1 for older patients.
Original posting: A new report from the United States Department of Health and Human Services (HHS) shows that hospital stays for patients with hepatitis C have been on the rise since 2005, largely due to the increase of injection drug use in the opioid epidemic.
There are 3 different viruses that cause hepatitis, a condition marked by inflammation of the liver. Hepatitis C is a contagious blood-borne infection that is today mostly spread in the United States through shared needles and syringes used to inject drugs. Less commonly, the virus can spread through sexual contact or by sharing personal items such as razors with an infected individual. Acute hepatitis C develops within the first 6 months of exposure to the virus. Symptoms can include fatigue, fever, nausea, vomiting, and abdominal pain; however, up to 80% of individuals with the acute infection do not experience symptoms. When the virus persists in the body, the infection can become chronic and last a lifetime, leading to serious liver problems such as cirrhosis or cancer.
The Centers for Disease Control and Prevention (CDC) notes that about 30,500 cases of hepatitis C were reported in the United States in 2014, while there are as many as 3.9 million individuals in the country living with chronic hepatitis C. In 2014, the United States saw 19,659 reported hepatitis C-related deaths, up from 11,849 deaths in 2005. Now the HHS’s Agency for Healthcare Research and Quality has released a Healthcare Cost and Utilization Project (HCUP) Statistical Brief, a report detailing findings on hepatitis C trends in the United States from 2005 to 2014. The report notes that the number of acute hepatitis C cases tripled from 2010 to 2015, largely as a result of the opioid epidemic, with mortality rates for those infected also on the rise.