Hepatitis C eradication by direct-acting antivirals improved carotid atherosclerosis in patients with severe fibrosis regardless of the presence of additional metabolic risk factors, according to recently published data.
“Emerging data … support a link between HCV infection and cardiovascular alterations,” Salvatore Petta, MD, PhD, from the Università di Palermo, Italy, and colleagues wrote. “In our cohort of HCV patients with severe fibrosis and, in two-thirds of cases, compensated cirrhosis, HCV eradication by DAA improved carotid atherosclerosis in terms of reduction of both [intima-media thickness (IMT)] and carotid thickening.”
The study comprised 182 patients with advanced chronic HCV or compensated cirrhosis due to HCV who underwent DAA therapy. As controls, Petta and colleagues reviewed data of 76 patients with HCV who previously underwent observation for atherosclerosis progression and had not undergone DAA therapy.