Patients with hepatitis C genotype 3 with compensated cirrhosis achieved a sustained virologic response rate higher than 90% after treatment with Epclusa with or without ribavirin, according to results of a recently published phase 3 study.
According to Rafael Esteban, MD, from the Hospital Universitario Val d’Hebron in Spain, and colleagues, these results were consistent with previous studies. Additionally, response rates were numerically higher in patients treated with ribavirin, largely due to the impact of baseline NS5A resistance-associated substitutions (RASs).
The researchers randomly assigned 204 patients to receive Epclusa (sofosbuvir/velpatasvir, Gilead Sciences) with ribavirin (n = 103) or without ribavirin (n = 101) for 12 weeks. At follow-up, SVR rates were 96% (95% CI, 90.4-98.9) for the ribavirin group and 91% (95% CI, 83.8-95.8) for the group without ribavirin.