Note: This is a very good article on the difficulties of developing a protective vaccine against HCV. Alan
Experts in a recent review stated that an effective hepatitis C vaccine is critical for significant global control of the infection in combination with increased screening and treatment.
However, there are several barriers to HCV vaccine development, including virus diversity, limited models for testing vaccines, and incomplete understanding of protective immune responses.
“Although pharmaceutical companies invest in drug development, vaccine development requires investment from sources beyond government and charitable foundations,” Justin R. Bailey, MD, PhD, from the Johns Hopkins University School of Medicine in Maryland, and colleagues wrote. “A prophylactic HCV vaccine is an important part of a successful strategy for global control. Although development is not easy, the quest is a worthy challenge.”