AASLD 2018: AASLD FOUNDATION Abstract Award Recipient
Abstract: #148 Sustained Virologic Responses Reduces the Incidence of Extrahepatic Manifestations in Chronic Hepatitis C Infection – Carmine Ross, et. al., By Alan Franciscus
This study evaluated the effect of hepatitis C (HCV) treatment with interferon-based therapies on extrahepatic manifestations (diabetes, chronic kidney disease, stroke, heart disease, osteoporosis and mood disorders such as depression). The results compared patients cured and not cured. Included in the analysis were 10,566 HCV patients that were followed for up to 10 years. The overall cure rate in this interferon-based therapy was 57%. All extrahepatic manifestations (diabetes, chronic kidney disease, end-stage kidney disease, stroke, osteoporosis with fractures, and mood disorders) improved except heart disease.
Conclusion: Treatment and cure of HCV significantly reduced extrahepatic manifestations of HCV.
Editorial Comments: This was a retrospective study of people treated with interferon-based therapies. Still, since this is a large long-term study it provides valuable information that treatment and cure significantly reduce many extrahepatic manifestations of HCV.Share This Page