A population-based study of 1.7 million-plus individuals tested for hepatitis C virus (HCV) has found further evidence that reinfection rates are elevated in people who inject drugs (PWIDs), even after being successfully treated with direct-acting antiviral (DAA) therapy.
The findings from the research team at the British Columbia Center for Disease Control and the University of British Columbia (UBC), presented at the Association for the Study of Liver Diseases (AASLD; The Liver Meeting) in San Francisco, CA, also suggest that opiate agonist therapy (OAT) could be a viable combatant for reinfection rates.
Led by Carmine Rossi, PhD, of UBC, investigators analyzed the clinical outcomes of HCV patients in Canada treated with DAAs between January 2014 and July 2017. Qualified patients had achieved sustained virologic response (SVR) and had been subjected to at least 1 subsequent HCV RNA test for reinfection. They defined reinfection as a single positive RNA test after reaching SVR.