Glecaprevir/pibrentasvir, an oral pangenotypic direct-acting antiviral (DAA) medication administered once-daily, was found to be both safe and effective in the treatment of chronic hepatitis C virus (HCV) infection in patients ≥65 years old, according to the results of a recently published retrospective analysis.
Due to the limited amount of published literature analyzing treatment options for older chronic HCV infection patients, the study authors aimed to determine the efficacy and tolerability of glecaprevir/pibrentasvir in this population. “Data were pooled for treatment-naïve and -experienced patients with chronic HCV genotype (GT) 1–6 infections who received glecaprevir/pibrentasvir for 8, 12, or 16 weeks in 9 Phase 2 and 3 trials,” the study authors explained. Outcomes of the study included the percentage of patients who attained sustained virologic response 12 weeks post-treatment (SVR12; HCV RNA<15 IU/mL) as well as adverse events (AEs), which were compared for patients ≥65 years and <65 years.
Of a total of 2369 patients enrolled in the trials, 328 (14%) were ≥65 years old. Demographics of this older population included: 42% had GT1, 34% had GT2, 40% were treatment-experienced, and 20% had compensated cirrhosis. The study authors reported that SVR12 rates did not differ significantly for patients ≥65 years old and patients <65 years old (P =.555). “Glecaprevir/pibrentasvir treatment resulted in SVR12 rates of 97.9% (95% CI, 96.3–99.4; n/N = 321/328) for patients aged ≥65 years and 97.3% (95% CI, 96.6–98.0; n/N = 1986/2041) for patients aged <65 years.”