According to results of a retrospective cohort study of patients with hepatitis C viral (HCV)-related hepatocellular carcinoma (HCC) who had achieved a complete response (CR) to anticancer treatment, subsequent direct-acting anti-hepatitis C viral therapy was not associated with recurrence of HCC. This study was published online in Gastroenterology.
Previous research had shown an association between achievement of a sustained hepatitis C viral response with interferon-based therapy administered following curative treatment for HCC and a decreased likelihood of disease recurrence. The current study was conducted to investigate whether direct-acting antiviral therapy administered in the same setting had an impact on the recurrence of disease in this population.
A total of 793 patients from 31 different sites in the United States and Canada who had achieved a complete response (CR) following treatment for HCV-related HCC during the period of 2013 to 2017 were included in the analysis. The percentages of patients who had or had not received subsequent direct-acting antiviral therapy were 38.3% and 61.7%, respectively. The HCC recurrence rate was 42.1% in the former group and 58.9% in the latter group.