Note: Not sure what this study really means for the long-term since the study follow-up period was only 36 weeks. Alan
Low levels of free testosterone are common among men with chronic hepatitis C infection following SVR and persist after HCV clearance, according to findings from a prospective, longitudinal cohort study.
“Previous research has shown that low total testosterone (TT), low free testosterone (FT), and elevated sex hormone-binding globulin (SHBG) are extrahepatic manifestations of chronic HCV when compared with healthy controls,” Chloe S. Chaudhury, MD,post-baccalaureate research fellow at the National Institute of Allergy and Infectious Diseases, and colleagues wrote. “There is now a need for studies to examine the effect of HCV and HCV viral clearance on long-term testosterone levels and hypogonadal status.”
To evaluate testosterone levels and the prevalence of low testosterone in men with HCV, Chaudhury and colleagues enrolled 327 patients with chronic HCV infection, including 150 who were coinfected with HIV. They also evaluated a subset of 85 men who had recorded testosterone levels pre-HCV treatment and after SVR. The median follow-up duration was 36 months.