Causes of death in England among persons with the diagnosis of HCV were determined through record linkage. Linking persons ≥1yrs with anti-HCV/HCV-PCR tests reported to PHE sentinel surveillance during 2002-2016 to death registrations from the Office for National Statistics during 2008-2016, researchers identified death of 8.6% of the 204,265 with evidence of HCV. The leading underlying causes of death were external causes (accidental poisoning from drugs) and liver disease (end stage liver disease, liver cancer, hepatitis, alcohol and non-alcohol related); 18% and 34.5%, respectively. Persons with evidence of HCV had a lower median age of death than the general population (53 years vs 81 years). New HCV treatments have led to a relative reduction in liver–related deaths in 2016 compared to 2015. This study supports that for monitoring all-cause mortality among those with HCV and quantifying underreporting of HCV in death registrations, data linkage between laboratory diagnosis and deaths data is an important tool.