According to a study published in Hepatology, small dense LDL cholesterol independently predicted cardiovascular disease events among liver transplant recipients, according to a study published in Hepatology.
“The present study employs detailed lipoprotein sub-particles to link specific proteins with CVD outcomes using a prospective cohort and provides valuable information that can be readily incorporated into clinical practice to hopefully improve clinical outcomes,” Mohammad B. Siddiqui, MD, from the Virginia Commonwealth University, and colleagues wrote. “The generation of the atherogenic [small dense LDL cholesterol (sdLDL-C)] likely results from insulin resistance, exposure to chronic immunosuppression and fatty liver after LT.”
The researchers included 130 liver transplant recipients in the study. The primary etiologies for liver transplantation included hepatitis C, nonalcoholic steatohepatitis and alcohol-related cirrhosis. The prevalence of cardiometabolic conditions at baseline included diabetes (35%), hypertension (82%), and dyslipidemia (40%).