ILC 2019: German and US studies confirm the efficacy and safety of G/P in a broad range of individuals with HCV infection and other comorbidities, showing improvements in mental and physical well-being
Chronic infection with HCV remains a leading cause of morbidity and mortality, with an estimated 71 million individuals infected worldwide. The availability of direct-acting antivirals (DAAs) has transformed the outlook for people with HCV infection, with recent drug development efforts focusing on simplifying treatment. Glecaprevir/pibrentasvir (G/P) is a fixed-dose pan-genotypic DAA combination tablet that was approved in Europe in July 2017 for the treatment of adults with HCV infection. In Phase 2 and 3 studies, G/P treatment led to an SVR in >95% of recipients, with no safety issues emerging. Real-world experience with the treatment is gradually expanding, and several post-authorization studies have recently been reported.