Patients with the hepatitis C virus (HCV) who received a 16-week regimen of glecaprevir and pibrentasvir (Mavyret) achieved high sustained virologic response (SVR) rates after previous treatments had failed, new findings show.
An international team of researchers studied 91 individuals with chronic HCV — 87 with genotype 1, and 4 with genotype 4. These patients had prior failures when treated with direct-acting antiviral (DAA) therapies that consisted of at least 1 NS3/4A protease and/or NS5A inhibitor-containing medication.
With glecaprevir and pibrentasvir (G/P), the SVR rate was 89% after 12 weeks and 91% after 16 weeks. The patients received a 3-pill, once-a-day dose of 300 mg/120 mg.