Today in the United States, 25% of HIV-positive people are also infected with hepatitis C (HCV), a blood-borne virus that attacks the liver, eventually leading to cirrhosis and cancer. Unlike HIV, HCV can be cured thanks to a new class of drugs called direct-acting antivirals (DAAs), which were introduced in 2013.
Because coinfection with HIV and HCV more than triples a person’s risk for liver disease and complicates HIV treatment management, coinfected people should be prioritized for DAA treatment, according to the AASLD/IDSA guidelines.
“We now have incredible medications that can get rid of HCV in the majority of people that are infected,” including people with HIV, said John Nelson, Ph.D., C.N.S., C.P.N.P., program director of the AIDS Education & Training Center National Coordinating Resource Center (AETC NCRC) at Rutgers School of Nursing. “However, we are not seeing great rates of cure simply because people are not being given the [DAA] medication,” said Nelson.
Coinfection with HIV and hepatitis C virus (HCV) is a common occurrence, with approximately 25% of HIV-infected patients in the United States being HCV-positive as well. According to the Centers for Disease Control and Prevention (CDC), HIV-HCV coinfection significantly increases patient risk for developing liver disease, often leading to liver-related death in coinfected individuals. A group based in France recently presented research they hope can lead to the eradication of HIV-HCV coinfection, potentially paving the way to rid the world of HCV in HIV-positive patients. At the 2017 Conference on Retroviruses and Opportunistic infections (CROI),
At the 2017 Conference on Retroviruses and Opportunistic infections (CROI), lead investigator, Victor Virlogeux, MD, from the Institut national de la santé et de la recherche médicale (INSERM), presented his group’s research on the eradication of HIV-HCV coinfection within the next decade. Dr. Virlogeux’s group utilized mathematical modeling to make projections on the impact direct-acting antiviral drugs (DAAs) will have on HIV-HCV infections over the next 10 years. The study utilized data, including
The study utilized data, including incidence of infection and treatment information, from the DatAIDS cohort, a collaborative effort between 15 HIV treatment centers in France. The authors examined multiple risk groups including: high-risk men who have sex with men (MSM), low-risk MSM, female and male heterosexuals, intravenous drug users (IVDU), as well as patients in additional risk categories. The researchers also examined the undiagnosed HIV-HCV coinfected population by utilizing a previously published model. Using this information, the authors examined the effect of increasing DAA coverage on HCV incidence and prevalence in the different risk groups.